The expression and relaxant effect of bitter taste receptors in human bronchi.
Identifieur interne : 001105 ( Main/Exploration ); précédent : 001104; suivant : 001106The expression and relaxant effect of bitter taste receptors in human bronchi.
Auteurs : Stanislas Grassin-Delyle [France] ; Charlotte Abrial ; Sarah Fayad-Kobeissi ; Marion Brollo ; Christophe Faisy ; Jean-Claude Alvarez ; Emmanuel Naline ; Philippe DevillierSource :
- Respiratory research [ 1465-993X ] ; 2013.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Bronches (), Bronches (métabolisme), Bronchoconstriction (), Bronchoconstriction (physiologie), Bronchodilatateurs (métabolisme), Caféine (pharmacologie), Chloroquine (pharmacologie), Femelle, Goût (physiologie), Humains, Mâle, Pipéridines (pharmacologie), Récepteurs couplés aux protéines G (), Récepteurs couplés aux protéines G (agonistes), Récepteurs couplés aux protéines G (métabolisme), Récepteurs de surface cellulaire (), Récepteurs de surface cellulaire (agonistes), Récepteurs de surface cellulaire (métabolisme), Strychnine (pharmacologie), Sujet âgé, Sujet âgé de 80 ans ou plus, Transduction du signal (), Transduction du signal (physiologie).
- MESH :
- agonistes : Récepteurs couplés aux protéines G, Récepteurs de surface cellulaire.
- métabolisme : Bronches, Bronchodilatateurs, Récepteurs couplés aux protéines G, Récepteurs de surface cellulaire.
- pharmacologie : Caféine, Chloroquine, Pipéridines, Strychnine.
- physiologie : Bronchoconstriction, Goût, Transduction du signal.
- Adulte, Adulte d'âge moyen, Bronches, Bronchoconstriction, Femelle, Humains, Mâle, Récepteurs couplés aux protéines G, Récepteurs de surface cellulaire, Sujet âgé, Sujet âgé de 80 ans ou plus, Transduction du signal.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Bronchi (drug effects), Bronchi (metabolism), Bronchoconstriction (drug effects), Bronchoconstriction (physiology), Bronchodilator Agents (metabolism), Caffeine (pharmacology), Chloroquine (pharmacology), Female, Humans, Male, Middle Aged, Piperidines (pharmacology), Receptors, Cell Surface (agonists), Receptors, Cell Surface (drug effects), Receptors, Cell Surface (metabolism), Receptors, G-Protein-Coupled (agonists), Receptors, G-Protein-Coupled (drug effects), Receptors, G-Protein-Coupled (metabolism), Signal Transduction (drug effects), Signal Transduction (physiology), Strychnine (pharmacology), Taste (physiology).
- MESH :
- chemical , agonists : Receptors, Cell Surface, Receptors, G-Protein-Coupled.
- chemical , drug effects : Receptors, Cell Surface, Receptors, G-Protein-Coupled.
- chemical , metabolism : Bronchodilator Agents, Receptors, Cell Surface, Receptors, G-Protein-Coupled.
- drug effects : Bronchi, Bronchoconstriction, Signal Transduction.
- metabolism : Bronchi.
- chemical , pharmacology : Caffeine, Chloroquine, Piperidines, Strychnine.
- physiology : Bronchoconstriction, Signal Transduction, Taste.
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged.
Abstract
Bitter-taste receptors (TAS2Rs) have recently been involved in the relaxation of mouse and guinea pig airways, and increased expression of TAS2Rs was shown in blood leucocytes from asthmatic children. We sought to identify and characterize the TAS2Rs expressed in isolated human bronchi and the subtypes involved in relaxation.
DOI: 10.1186/1465-9921-14-134
PubMed: 24266887
Affiliations:
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Le document en format XML
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uniqKey="Abrial C" first="Charlotte" last="Abrial">Charlotte Abrial</name></author><author><name sortKey="Fayad Kobeissi, Sarah" sort="Fayad Kobeissi, Sarah" uniqKey="Fayad Kobeissi S" first="Sarah" last="Fayad-Kobeissi">Sarah Fayad-Kobeissi</name></author><author><name sortKey="Brollo, Marion" sort="Brollo, Marion" uniqKey="Brollo M" first="Marion" last="Brollo">Marion Brollo</name></author><author><name sortKey="Faisy, Christophe" sort="Faisy, Christophe" uniqKey="Faisy C" first="Christophe" last="Faisy">Christophe Faisy</name></author><author><name sortKey="Alvarez, Jean Claude" sort="Alvarez, Jean Claude" uniqKey="Alvarez J" first="Jean-Claude" last="Alvarez">Jean-Claude Alvarez</name></author><author><name sortKey="Naline, Emmanuel" sort="Naline, Emmanuel" uniqKey="Naline E" first="Emmanuel" last="Naline">Emmanuel Naline</name></author><author><name sortKey="Devillier, Philippe" sort="Devillier, Philippe" uniqKey="Devillier P" first="Philippe" last="Devillier">Philippe 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sortKey="Abrial, Charlotte" sort="Abrial, Charlotte" uniqKey="Abrial C" first="Charlotte" last="Abrial">Charlotte Abrial</name></author><author><name sortKey="Fayad Kobeissi, Sarah" sort="Fayad Kobeissi, Sarah" uniqKey="Fayad Kobeissi S" first="Sarah" last="Fayad-Kobeissi">Sarah Fayad-Kobeissi</name></author><author><name sortKey="Brollo, Marion" sort="Brollo, Marion" uniqKey="Brollo M" first="Marion" last="Brollo">Marion Brollo</name></author><author><name sortKey="Faisy, Christophe" sort="Faisy, Christophe" uniqKey="Faisy C" first="Christophe" last="Faisy">Christophe Faisy</name></author><author><name sortKey="Alvarez, Jean Claude" sort="Alvarez, Jean Claude" uniqKey="Alvarez J" first="Jean-Claude" last="Alvarez">Jean-Claude Alvarez</name></author><author><name sortKey="Naline, Emmanuel" sort="Naline, Emmanuel" uniqKey="Naline E" first="Emmanuel" last="Naline">Emmanuel Naline</name></author><author><name sortKey="Devillier, Philippe" sort="Devillier, Philippe" uniqKey="Devillier P" first="Philippe" last="Devillier">Philippe Devillier</name></author></analytic><series><title level="j">Respiratory research</title><idno type="eISSN">1465-993X</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Bronchi (drug effects)</term><term>Bronchi (metabolism)</term><term>Bronchoconstriction (drug effects)</term><term>Bronchoconstriction (physiology)</term><term>Bronchodilator Agents (metabolism)</term><term>Caffeine (pharmacology)</term><term>Chloroquine (pharmacology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Piperidines (pharmacology)</term><term>Receptors, Cell Surface (agonists)</term><term>Receptors, Cell Surface (drug effects)</term><term>Receptors, Cell Surface (metabolism)</term><term>Receptors, G-Protein-Coupled (agonists)</term><term>Receptors, G-Protein-Coupled (drug effects)</term><term>Receptors, G-Protein-Coupled (metabolism)</term><term>Signal Transduction (drug effects)</term><term>Signal Transduction (physiology)</term><term>Strychnine (pharmacology)</term><term>Taste (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Bronches ()</term><term>Bronches (métabolisme)</term><term>Bronchoconstriction ()</term><term>Bronchoconstriction (physiologie)</term><term>Bronchodilatateurs (métabolisme)</term><term>Caféine (pharmacologie)</term><term>Chloroquine (pharmacologie)</term><term>Femelle</term><term>Goût (physiologie)</term><term>Humains</term><term>Mâle</term><term>Pipéridines (pharmacologie)</term><term>Récepteurs couplés aux protéines G ()</term><term>Récepteurs couplés aux protéines G (agonistes)</term><term>Récepteurs couplés aux protéines G (métabolisme)</term><term>Récepteurs de surface cellulaire ()</term><term>Récepteurs de surface cellulaire (agonistes)</term><term>Récepteurs de surface cellulaire (métabolisme)</term><term>Strychnine (pharmacologie)</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Transduction du signal ()</term><term>Transduction du signal (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="agonists" xml:lang="en"><term>Receptors, Cell Surface</term><term>Receptors, G-Protein-Coupled</term></keywords><keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Receptors, Cell Surface</term><term>Receptors, G-Protein-Coupled</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Bronchodilator Agents</term><term>Receptors, Cell Surface</term><term>Receptors, G-Protein-Coupled</term></keywords><keywords scheme="MESH" qualifier="agonistes" xml:lang="fr"><term>Récepteurs couplés aux protéines G</term><term>Récepteurs de surface cellulaire</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Bronchi</term><term>Bronchoconstriction</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Bronchi</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Bronches</term><term>Bronchodilatateurs</term><term>Récepteurs couplés aux protéines G</term><term>Récepteurs de surface cellulaire</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Caféine</term><term>Chloroquine</term><term>Pipéridines</term><term>Strychnine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Caffeine</term><term>Chloroquine</term><term>Piperidines</term><term>Strychnine</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Bronchoconstriction</term><term>Goût</term><term>Transduction du signal</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Bronchoconstriction</term><term>Signal Transduction</term><term>Taste</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Bronches</term><term>Bronchoconstriction</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Récepteurs couplés aux protéines G</term><term>Récepteurs de surface cellulaire</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bitter-taste receptors (TAS2Rs) have recently been involved in the relaxation of mouse and guinea pig airways, and increased expression of TAS2Rs was shown in blood leucocytes from asthmatic children. We sought to identify and characterize the TAS2Rs expressed in isolated human bronchi and the subtypes involved in relaxation.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><noCountry><name sortKey="Abrial, Charlotte" sort="Abrial, Charlotte" uniqKey="Abrial C" first="Charlotte" last="Abrial">Charlotte Abrial</name><name sortKey="Alvarez, Jean Claude" sort="Alvarez, Jean Claude" uniqKey="Alvarez J" first="Jean-Claude" last="Alvarez">Jean-Claude Alvarez</name><name sortKey="Brollo, Marion" sort="Brollo, Marion" uniqKey="Brollo M" first="Marion" last="Brollo">Marion Brollo</name><name sortKey="Devillier, Philippe" sort="Devillier, Philippe" uniqKey="Devillier P" first="Philippe" last="Devillier">Philippe Devillier</name><name sortKey="Faisy, Christophe" sort="Faisy, Christophe" uniqKey="Faisy C" first="Christophe" last="Faisy">Christophe Faisy</name><name sortKey="Fayad Kobeissi, Sarah" sort="Fayad Kobeissi, Sarah" uniqKey="Fayad Kobeissi S" first="Sarah" last="Fayad-Kobeissi">Sarah Fayad-Kobeissi</name><name sortKey="Naline, Emmanuel" sort="Naline, Emmanuel" uniqKey="Naline E" first="Emmanuel" last="Naline">Emmanuel Naline</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Grassin Delyle, Stanislas" sort="Grassin Delyle, Stanislas" uniqKey="Grassin Delyle S" first="Stanislas" last="Grassin-Delyle">Stanislas Grassin-Delyle</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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